all MUGEN mice

muMTo, muKO


General Information
MUGEN ID
M223009
Common Line Name
muMTo, muKO
Research Applications Type
MODEL OF IMMUNE PROCESSES
Contact
Holmdahl Rikard
Institution
ULUND
Research Applications Comments
IgH knockout

Availability
Repository Available Background State Type
JACKSONS C57BL/6 live mouse mutant strain
JACKSONS C57BL/10 live mouse mutant strain
EMMA C57BL/6 cryopreserved embryos mutant stock
ULUND C57/BL10.Aq(RIII) live mouse congenic strain

Genetic Background
DNA Origin Targeted Background Host Background Backcrossing Strain Backcrosses
129S2/SvPas D3 C57BL/6 C57BL/10 >=10

Strain Information
Designation JAX ID EMMA ID
B10;129-Igh-6tm1Cgn 002249 EM:00001

Allele & Mutations
Name Symbol Mutation(s)
targeted mutation 1, University of Cologne Igh-6tm1Cgn targeted mutation

Gene(s)
Name Comment Chromosome
immunoglobulin heavy chain 6 (heavy chain of IgM) not provided yet 12

Handling & Genotyping Instructions
Name Type

Mammalian Phenotype Ontologies
 
MP Term: immune system phenotype>abnormal immune system morphology>abnormal immune system cell morphology>abnormal immune cell development>abnormal leukopoiesis>abnormal mononuclear leukocyte morphology/development>abnormal lymphocyte morphology>absent lymphocyte>absent B cells
PATO Logical Definition:  lacking physical part towards B cell
 

References
Name Type Comment
Kitamura et al., 1991 Nature 350(6317):423-6 Webblink A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene.

Author's Comments
 
muMT in the constant region of the Igh-6 gene. Mutation of the gene by insertion of neo gene into membrane domain-coding exon. Normal development of B cells in heterozygous animals, absent in homozygotes; development stops at pre-B state.